Histrelin For Equines

Histrelin is a synthetic GnRH used to promote ovulation in horses. It possesses similar clinical efficacy in inducing ovulation in horses as deslorelin or hCG, but differs from the natural decapeptide GnRH in two amino acid substitutions.

Histrelin is an even more potent GnRH analogue than deslorelin, but with similar clinical efficacy in inducing ovulation in horses as deslorelin or hCG. Histrelin differs from the natural decapeptide GnRH in two amino acid substitutions.¹

Results from studies suggested that 0.5 mg and 1 mg doses of histrelin resulted in ovulation in > 95% of estrus mares treated after follicle size and uterine edema scores met normal farm treatment parameters.² Recently, a sustained-release (biorelease) formulation of histrelin was found to effectively induce ovulation within 2 days after administration.

Excepting very few examples of animals that proved to be allergic to histrelin, very few adverse effects have been reported. It is advised to call your veterinarian for medical advice about side effects regarding histrelin use in mares. In rare cases, irritation has been reported at injection sites ¹. Once again, it is advisable to consult your veterinarian.

Histrelin 0.5 mg/ml injectable by NexGen possesses similar clinical efficacy in inducing ovulation in horses as deslorelin or hCG, but differs from the natural decapeptide GnRH in two amino acid substitutions.

¹Pinto, C., DVM. Hormones and Breeding, AAEP Proceedings, Reproductive Endocrinology, Vol. 59, 2013.

²Burns, P., Gilley, R. Histrelin and its use in Mares, Keeping Current in Equine Theriogenology: The Mare, BioRelease Technologies 3rd Annual Review, November 15, 2011.

FOR RX ONLY: A valid prescription from a licensed veterinarian is required for dispensing this medication.