BUSERELIN 1 MG/ML (10 ML)
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- Product Type:
- Intramuscular / Intravenous
- Therapeutic Class:
- GnRH Agonist
Buserelin is a synthetic gonadotropin-releasing hormone (GnRH) analogue that is designed to alter hormone levels and is typically employed in order to induce ovulation in cyclic mares. Inducing ovulation in a cyclic mare is often necessary. For this purpose, hCG has frequently been used, but efficacy often diminishes after successive administrations.1
Recently reported trials demonstrate that treating mares with buserelin 9 or 10 days after ovulation increases pregnancy rates.
Early embryonic loss is a major cause of sub-fertility in mares. Progesterone produced in the ovary by the corpus luteum maintains the early pregnancy. The embryo must signal its presence and ensure the corpus luteum is maintained in order to survive the first few weeks of pregnancy. In other species, luteal function in pregnant animals starts to diverge from that of non-pregnant animals between 11 and 14 days after ovulation. It is therefore, considered to be a critical time for the maintenance of the pregnancy... Treatment with 20µg or 40µg buserelin 9 or 10 days after ovulation significantly increased the overall pregnancy rate by up to 10% in mares.1
Buserelin acts the same as the natural LH/FSH releasing hormone produced in the hypothalamus. It causes simultaneous release of luteinising hormone (LH) and follicle stimulating hormone (FSH) from the pituitary.2
Recent studies have shown that buserelin:
- Is at least 50 – 60 times more effective than Gonadorelin, the alternative GnRH active (as measured in FSH and LH response)
- Stimulates high production of LH for efficient induction of ovulation and better support of corpus luteum formation and early luteal function
- Is the most potent GnRH analogue of standard formulation on the veterinary market2
Buserelin for horses (1 mg/ml) by NexGen is as effective as hCG in inducing ovulation between 24 and 48 hours after initiation of treatment without the diminishing effectiveness of hCG over time.
1Theriogenology 55(8):1679-95 · June 2001
2Nawito et al. (1977); Reeves et al. (1980); Loumaye et al. (1982); Chenault et al. (1990). msd-animal-health.co.nz.
FOR RX ONLY: A valid prescription from a licensed veterinarian is required for dispensing this medication.