BUSERELIN 1 MG/ML / HCG 3000 IU/ML
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- Product Type:
- Intramuscular / Intravenous
- Suggested Dosing:
- 1 ML / 1000 LB
- Therapeutic Class:
- GnRH Agonist
Buserelin For Equines
Buserelin is a synthetic gonadotropin-releasing hormone (GnRH) analogue that is designed to alter hormone levels and is typically employed in order to induce ovulation in cyclic mares. Inducing ovulation in a cyclic mare is often necessary.
Recently reported trials demonstrate that treating mares with buserelin 9 or 10 days after ovulation increases pregnancy rates.
Early embryonic loss is a major cause of sub-fertility in mares. Progesterone produced in the ovary by the corpus luteum maintains the early pregnancy. The embryo must signal its presence and ensure the corpus luteum is maintained in order to survive the first few weeks of pregnancy. In other species, luteal function in pregnant animals starts to diverge from that of non-pregnant animals between 11 and 14 days after ovulation. It is therefore, considered to be a critical time for the maintenance of the pregnancy... Treatment with 20µg or 40µg buserelin 9 or 10 days after ovulation significantly increased the overall pregnancy rate by up to 10% in mares.1
Buserelin acts the same as the natural LH/FSH releasing hormone produced in the hypothalamus. It causes simultaneous release of luteinising hormone (LH) and follicle stimulating hormone (FSH) from the pituitary.2
Recent studies have shown that buserelin:
- Is at least 50 – 60 times more effective than Gonadorelin, the alternative GnRH active (as measured in FSH and LH response)
- Stimulates high production of LH for efficient induction of ovulation and better support of corpus luteum formation and early luteal function
- Is the most potent GnRH analogue of standard formulation on the veterinary market2
Human chorionic gonadotrophin (hCG) has often been used for the purpose of inducing ovulation in cyclic mares, but the efficacy of hCG alone tends to diminish after successive administrations.1 Studies have shown that buserelin combined with hCG significantly mitigates this drop in efficacy.
In a recent study, four ovulation protocols were implemented in different groups of mares once a follicle reached 35 mm along with a uterine edema score of 2 based on ultrasound exam. These groups consisted of:
- Spontaneous ovulation without any drug influence
- 40 ug of buserelin (GnRH analogue) as a single IM dose
- 1500 IU hCG as a single IV dose
- 3000 IU hCG as a single IV dose
As expected, the non-treated mares had the slowest follicular growth. The mares treated with 1500 IU hCG experienced the fastest follicular growth of 6.3 mm, with ovulation in 1.53 days. Buserelin-treated mares ovulated in 1.83 days; mares given 3000 IU hCG ovulated in 2.1 days; and the non-treated group ovulated in 3.2 days.3
Buserelin (1 mg/ml) with hCG by NexGen buserelin is as effective as hCG by itself in inducing ovulation between 24 and 48 hours after initiation of treatment without the diminishing effectiveness of hCG over time.
1Theriogenology 55(8):1679-95 · June 2001
2Nawito et al. (1977); Reeves et al. (1980); Loumaye et al. (1982); Chenault et al. (1990). msd-animal-health.co.nz.
3Loving, N., DVM. Ovulation Induction in Mares. Equimanagement, May, 2018.
FOR RX ONLY: A valid prescription from a licensed veterinarian is required for dispensing this medication.